Welcome
Conference starts 26th June 2011
The organisers welcome you to Manchester for the 17th International Conference on Cytochrome P450, at The University of Manchester’s new conference facilities from the 26th to 30th of June, 2011. Manchester, now the UK’s second city, was the trail-blazing spirit behind the Industrial Revolution, which led the world into the modern industrial era and created a young dynamic city (whose symbol is the worker bee, which has inspired our logo). Chatsworth House (steeped in history, and in the heart of the Peak District), along with Manchester United’s famous Old Trafford Stadium (the fabled ‘Theatre of Dreams’) are the major excursions planned.
In addition to the many attractions offered by Manchester and surroundings, we have an exciting programme of speakers in the tradition of previous meetings. This meeting places special emphasis on the recent breakthroughs in P450 structural biology and their impact on our understanding of P450 biochemistry. You are cordially invited to participate and contribute your research to our international audience. There will be ample opportunities for seminar presentations selected from submitted poster abstracts.
We look forward to seeing you in Manchester, June 2011!
At a glance...
Dennis Stuehr from the Lerner Institute, Cleveland USA will be talking about “When is a NO synthase not an NO synthase? Exploring the inherent NO dioxygenase activity of the NOS enzymes”.
Dennis is a world-leading researcher on the structure/function of the nitric oxide synthases (NOSs), and will present data on novel catalytic functions of NOS.
Cypex is the major sponsor for the P450 2011 meeting. Cypex was founded in 1999 in Dundee at the end of a joint commercial / academic LINK project at the University of Dundee funded in part by 14 pharmaceutical companies. The company was set up to manufacture high quality recombinant mammalian drug metabolising enzymes (primarily cytochrome P450s) in E. coli using the expression technology developed during the LINK project. Over the last twelve years the company’s product range has expanded significantly.
The P450 2011 conference will honour Klaus Ruckpaul. His contributions to the field include seminal work on P450 spin-state equilibria and key studies on the adrenodoxin reductase-adrenodoxin complex structure. Klaus co-organized the first International P450 Conference in Primosten (then Yugoslavia) in 1976, and organized the second meeting in Eberswalde (then East Germany) in 1978. His efforts in launching this series also helped forge links between P450 scientists from East and West of the Iron Curtain. The fruits of his efforts are seen in the continuing success of this series, now in its 17th incarnation in Manchester.
Abstract submission now live - submit your abstract now.
Mike Wester from Pfizer Global R&D, San Diego, USA will be talking about “P450 structures: Influencing Drug Discovery”.
Mike’s research is at the intersection of P450 structural biology and drug interactions / pharmacology. He will present an industrial perspective on the role of P450 structure in drug development.
December 2010: Invited speaker list finalised.
Eric Johnson from the Department of Molecular and Experimental Medicine, Scripps Inst, La Jolla, USA will be talking about “Structural biology of mammalian P450 enzymes”.
Eric is a pioneer in the field of mammalian P450 structural biology, whose research has been pivotal in providing several key human drug metabolizing CYP structures.
Fred Guengerich from the Center in Molecular Toxicology, Vanderbilt University, Nashville, USA will be talking about “Deciphering the functions of P450 enzymes”.
Fred is a world-leading researcher on the pharmacology and biochemistry of P450s. His seminar will focus on his efforts to determine functions for the numerous “orphan” CYPs, in order to define their physiological roles.
Mike Green from the Department of Chemistry, Penn State University, USA will be talking about “P450 compound I: Capture, characterization, and C-H bond activation”.
Mike’s research has led to the conclusive characterization of the compound I oxidant in the P450 catalytic cycle. This “holy grail” of P450 research was recently published in Science (330, 933-7, Nov. 2010).
June 2011: Programme finalised.
Paul Ortiz de Montellano from the School of Pharmacy, University of California, San Francisco will be talking about “The proximal iron ligand in P450 catalysis and inactivation”.
Paul is an award winning Biological Chemist who has made crucial contributions to our understanding P450 structure and function. His seminar will focus on relationships between heme iron ligand status and P450 functionality.
Sponsorship packages are available.
Steve Sligar from the Department of Biochemistry, University of Illinois, Urbana, USA will be presenting “Nanotechnology reveals the structure and function of membrane bound P450s”.
Steve’s studies on bacterial and eukaryotic P450 structure/function, electron transfer and thermodynamics have been crucial to our understanding of their redox functions. His seminar will contain exciting new analysis of membranous P450 enzymes embedded in nanodiscs.
Registration now live - register now.
Magnus Ingelman-Sundberg from Dept. of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden will be talking about “Epigenetic and postranslational control of P450 expression”.
Magnus is a world-leading Molecular Toxicologist whose research is focused in key areas relating to regulation of P450 expression and on the role of genetic polymorphisms in P450 drug metabolism and toxicity.
Mike Waterman from the “Department of Biochemistry, Vanderbilt University, Nashville, USA will be presenting “Structural basis of congenital adrenal hyperplasia”.
Mike has a long history of ground-breaking research on steroid metabolizing P450s, and will present new structural data on the steroid 21-hydroxylase CYP21, mutations in which give rise to the human steroid biosynthesis disorder Congenital Adrenal Hyperplasia.
